The body functions as one system where everything is connected.
We combine adaptogens from an integrative perspective, not in isolation.
Adaptogens work together to enhance their effect.
We support the body's natural intelligence, without forcing it.
For a long time, health has been approached one symptom at a time, searching for a single solution for each concern.
Systemic phytotherapy offers a different perspective, understanding that the body works as a system where everything is connected. Instead of relying on one ingredient for one goal, we combine adaptogenic plants that work together, respecting the body's natural complexity and supported by scientific expertise in selecting the right combinations.
We call that synergy.
Adaptoheal is built on a simple belief: nature is intelligent, and life performs better in synergy. That belief comes from real clinical experience.
Every formula follows what we call The Life Triangle, the idea that health depends on the balance between three pillars.
Biological Intelligence: Supporting the body's natural capacity to adapt, regulate, and respond to change.
Energy: Supporting the vitality your body draws on to meet daily demands.
Organization: Supporting balance and coordination across the body's systems so they function as one.
Before selecting a single adaptogen, we define the formula's purpose and how each ingredient can strengthen one or more of these pillars. The result is formulas where every adaptogen has a specific role and works in synergy with the others to support the body as a whole.
This approach comes from over 20 years of experience in integrative medicine, systemic phytotherapy, and adaptogenic plants.
Adaptoheal remains an independent adaptogen supplement company, formulated by the same founding team from day one.
An internal medicine physician specializing in integrative medicine, longevity, systemic phytotherapy, and the use of adaptogenic plants. He brings more than 20 years of experience in systemic phytotherapy to every Adaptoheal formula.
A graduate in Applied Nutrition with a Master's in Mindfulness. A specialist in integrative therapy and cellular health, she has always been driven to help people improve their everyday wellbeing.
Scientific Studies on Adaptogens
Published clinical studies on the adaptogenic ingredients in each Adaptoheal formula, with a direct link to the original publication on PubMed.
Arctic root – Rhodiola rosea
A randomised, double-blind, placebo-controlled study of SHR-5 in stress-related fatigue
Assessed fatigue, attention, depression, quality of life and cortisol response. The study reported improvement in several parameters related to fatigue and mental performance versus placebo.
American ginseng – Panax quinquefolius
Wisconsin Ginseng to improve cancer-related fatigue: N07C2
At 8 weeks, improvement in fatigue was significantly greater with ginseng than with placebo.
Korean/Asian ginseng – Panax ginseng
Antifatigue effects of Panax ginseng C.A. Meyer
The total fatigue score did not differ significantly from placebo, but there was significant improvement in mental fatigue and, at 2 g/day, in the fatigue VAS. Changes in oxidative markers were also observed.
Ashwagandha – Withania somnifera
Effect of Withania somnifera supplementation on muscle strength and recovery
Ashwagandha was associated with greater increases in bench-press and leg-extension strength, as well as differences in muscle recovery, body composition and testosterone.
Schisandra – Schisandra chinensis
Effect of Schisandra chinensis extracts and low-intensity exercise on muscle strength and mass
The Schisandra group showed a greater increase in knee-extensor strength than placebo. No differences were found in muscle mass or in several inflammatory and antioxidant markers.
Arctic root – Rhodiola rosea
Rhodiola rosea in stress-induced fatigue in physicians during night duty
A statistically significant improvement was observed in tests of mental performance, memory, concentration and perception during the first two weeks of treatment.
Siberian ginseng – Eleutherococcus senticosus
Effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism
A 12% increase in VO₂ peak and a 23% increase in time to exhaustion were reported, along with metabolic changes during exercise.
Ashwagandha – Withania somnifera
Stress-relieving and pharmacological actions of an Ashwagandha extract
Compared with placebo, there was a significant reduction in HAM-A and morning cortisol; the difference in DASS-21 did not reach statistical significance.
Maca – Lepidium meyenii
Pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen
40 km time trial performance improved from baseline, but the difference versus placebo was not significant. There was a difference versus placebo in sexual desire.
Arctic root – Rhodiola rosea
Effects of chronic Rhodiola rosea supplementation on sport performance and antioxidant capacity
No relevant differences were seen in VO₂max or exercise duration, but post-exercise lactate and creatine kinase levels were lower than with placebo.
Arctic root + Schisandra + Siberian ginseng
Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions
Two hours after administration, significant differences versus placebo were observed in attention, speed and accuracy during cognitive tasks under stress.
Arctic root + Schisandra + Siberian ginseng
Impact of Chisan (ADAPT-232) on quality of life and its efficacy as an adjuvant in acute non-specific pneumonia
The duration of antibiotic therapy needed for recovery was about 2 days shorter in the ADAPT-232 group. Better mental performance and quality-of-life results were also seen during recovery, with significant differences in QOL on the fifth day of convalescence.
Arctic root + Schisandra + Siberian ginseng
Efficacy of Adaptogens in Patients with Long COVID-19
Fewer patients had fatigue in the combination group on day 11 (28% vs. 43%; p=0.0157), and daily physical activity time increased significantly versus placebo. Only one adverse event was recorded in the study, and it occurred in the placebo group.
American ginseng – Panax quinquefolius
Efficacy of an extract of North American ginseng for preventing upper respiratory tract infections
Randomized, double-blind, placebo-controlled trial. 323 adults, 4 months. The treated group had fewer colds, a lower proportion of people with ≥2 colds, fewer symptom days and lower symptom scores.
Andrographis paniculata
A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection
Randomized, double-blind, placebo-controlled trial in 223 patients with uncomplicated upper respiratory tract infection. At 5 days, overall symptom scores were better than with placebo.
Panax ginseng
Immunomodulatory effects of two extracts of Panax ginseng C.A. Meyer
Randomized, double-blind trial in 60 healthy volunteers. It assessed chemotaxis, phagocytosis, NK activity and lymphocyte subsets over 8 weeks; several cell-function parameters increased with the ginseng extracts.
Echinacea purpurea
A proprietary extract from the echinacea plant enhances systemic immune response during a common cold
Controlled clinical trial in people with a naturally acquired cold. The intervention was associated with changes in leukocytes, monocytes, neutrophils and NK cells, as well as a greater reduction in symptom scores versus placebo.
Shiitake – Lentinula edodes
Consuming Lentinula edodes Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention
52 healthy adults, 4 weeks. γδ-T cells, NK-T cells, secretory IgA, cytokines and CRP were assessed. Proliferation/activation of certain immune cells and sIgA increased.
Astragalus membranaceus
Efficacy and safety of Astragalus membranaceus in patients with seasonal allergic rhinitis
Six-week double-blind, placebo-controlled trial in 48 adults with seasonal allergic rhinitis. Symptoms, quality of life, IgE, IgG and eosinophils were assessed. Some favorable signals were observed, particularly for rhinorrhea and certain subgroups.
Cat's claw – Uncaria guianensis
Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee
Clinical trial in 45 patients with knee osteoarthritis, 30 treated and 15 on placebo. It assessed pain, tolerability and anti-inflammatory activity.
Maitake – Grifola frondosa
A phase I/II trial of a polysaccharide extract from Grifola frondosa in breast cancer patients: immunological effects
34 postmenopausal women previously treated for breast cancer. Several doses were studied over 3 weeks across multiple immune parameters. Measurable immune effects were found, some stimulatory and others inhibitory.
Reishi – Ganoderma lucidum
Effects of Ganopoly on the immune functions in advanced-stage cancer patients
34 patients with advanced cancer, 12 weeks of G. lucidum polysaccharide extract. In the 30 evaluable patients, changes from baseline were seen in cytokines, CD56+ cells and NK activity.
Turkey tail – Trametes versicolor
Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer
Phase I study in 11 women (9 completed) after radiotherapy. Doses of 3, 6 and 9 g/day were evaluated. Trends were observed in lymphocytes, NK activity and CD8+/CD19+ cells, along with tolerability.
Andrographis + Siberian ginseng
Early intervention with Kan Jang® to treat upper-respiratory tract infections
The combination significantly shortened the illness: 2.38 vs. 3.02 days, about 21% fewer sick days. It also significantly improved respiratory symptoms from day two and showed differences in leukocytes and ESR versus placebo.
Andrographis + Siberian ginseng
A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in acute upper respiratory tract infections including sinusitis
The overall symptom score improved significantly versus placebo. Differences were especially marked for headache, nasal and throat symptoms and general malaise, including in patients with sinusitis.
Andrographis + Siberian ginseng
Efficacy of Kan Jang® in Patients with Mild COVID-19
Clinical progression was 5.36% with the combination vs. 17.86% with placebo. Recovery was also faster, with greater reductions in cough, sore throat, runny nose and muscle pain.
Echinacea purpurea + Siberian ginseng (with Justicia adhatoda)
Randomized trial of a fixed combination KanJang in patients with upper respiratory tract infections
The full combination produced significant improvements in cough severity and frequency, mucus clearance, nasal congestion and the general feeling of illness. Recovery time was about 2 days shorter with the herbal formulations than with the comparator treatment.
Echinacea purpurea + Astragalus (with Glycyrrhiza glabra)
The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans
All three extracts activated immune cells, and the research found an additive effect on CD69 expression when they were used together.
Ginkgo biloba
Efficacy and safety of Ginkgo biloba extract EGb 761 in mild cognitive impairment with neuropsychiatric symptoms
The EGb 761 group showed differences versus placebo in executive/cognitive function tests such as the Trail Making Test, as well as improvements in neuropsychiatric symptoms.
Lion's mane – Hericium erinaceus
Improving effects of the mushroom Yamabushitake on mild cognitive impairment
Cognitive function scores were significantly higher than placebo at weeks 8, 12 and 16. After intake stopped, scores declined.
Bacopa monnieri
Does Bacopa monnieri improve memory performance in older persons?
Bacopa significantly improved verbal learning, memory acquisition and delayed recall versus placebo. Some gastrointestinal effects were reported.
Huperzine A
Clinical efficacy and safety of huperzine A in mild to moderate Alzheimer disease
Favorable differences were observed in ADAS-Cog, MMSE, activities of daily living and other clinical scales versus baseline and placebo.
Alpha-GPC – choline alfoscerate
Efficacy and safety of choline alphoscerate for amnestic mild cognitive impairment
The α-GPC group showed a significantly greater reduction in ADAS-Cog than placebo; no serious adverse events were reported.
Phosphatidylserine
Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study
Statistically significant differences versus placebo were reported in cognitive and behavioral parameters.
L-Theanine
Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control
L-theanine showed significant effects on attention in simple visuomotor tasks, although it did not improve all of the complex cognitive tasks evaluated.
Arctic root – Rhodiola rosea
Rhodiola rosea in stress-induced fatigue: mental performance of healthy physicians during night duty
Associative thinking, short-term memory, calculation, concentration and speed of perception were assessed. Mental performance improved significantly during the first two weeks of Rhodiola.
Gotu kola – Centella asiatica
Positive modulation of cognition and mood in the healthy elderly volunteer following administration of Centella asiatica
The highest dose was associated with improved working memory and changes in evoked potentials, as well as improvements in some subjective mood measures.
Korean white ginseng – Panax ginseng
Effects of white ginseng on reducing stress and tension by enhancing default mode network connectivity
White ginseng significantly reduced the composite stress index versus placebo and produced changes in functional connectivity of the default mode network, a brain network involved in internal cognitive processing.
Ginkgo + Arctic root (Rhodiola rosea)
Central additive effect of Ginkgo biloba and Rhodiola rosea on psychomotor vigilance task and short-term working memory accuracy
The combination of Ginkgo 60 mg + Rhodiola 500 mg produced a greater improvement than either ingredient alone in psychomotor vigilance and at every level of short-term working memory (p<0.01). The authors explicitly describe a central additive effect.
Ginkgo + Panax ginseng
The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers
The combination significantly improved the Memory Quality Index, with an average improvement of 7.5%, including working and long-term memory. The benefit was seen throughout the 12 weeks of treatment and after the washout.
Ginkgo + Panax ginseng
Modulation of cognition and mood following administration of single doses of Ginkgo biloba, ginseng, and a ginkgo/ginseng combination
The combination improved secondary memory and performance on the Serial Threes and Serial Sevens tasks at various time points after administration.
Chasteberry – Vitex agnus-castus
Treatment for the premenstrual syndrome with agnus castus fruit extract
Improvement in irritability, mood changes, headache, breast fullness and other symptoms was greater than with placebo. The response rate was 52% with Vitex vs. 24% with placebo.
Chasteberry – Vitex agnus-castus
Treatment for premenstrual syndrome with Vitex agnus castus: randomized multicenter placebo-controlled study
The premenstrual symptom diary score decreased more with Vitex than with placebo, with significant between-group differences and no serious adverse events.
Chasteberry – Vitex agnus-castus
Dose-dependent efficacy of the Vitex agnus castus extract Ze 440 in patients suffering from PMS
The 20 mg dose produced a significantly greater improvement in total symptom score than placebo and 8 mg. 30 mg provided no additional benefit over 20 mg.
Chasteberry – Vitex agnus-castus
Vitex agnus castus extract in luteal phase defects due to latent hyperprolactinaemia
The treated group showed a reduced prolactin response, normalization of shortened luteal phases and improved progesterone synthesis during the luteal phase.
Chasteberry – Vitex agnus-castus
Treatment of cyclical mastalgia with a solution containing a Vitex agnus castus extract
Breast pain intensity decreased faster with Vitex than with placebo, with significant differences in the first cycles.
Chasteberry – Vitex agnus-castus
Fluoxetine versus Vitex agnus castus extract in the treatment of PMDD
The proportion of responders was similar for fluoxetine and Vitex in this small study; fluoxetine had a greater effect on psychological symptoms and Vitex on physical symptoms.
Dong quai – Angelica sinensis
Does dong quai have estrogenic effects in postmenopausal women?
No differences versus placebo were found in endometrial thickness, vaginal maturation, hot flashes or the Kupperman index.
Wild yam – Dioscorea villosa
Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women
There were no significant differences versus placebo in hot flashes, menopausal symptoms, FSH, estradiol or progesterone.
Pau d'Arco – Tabebuia avellanedae
Safety and tolerability of Pau d'Arco for primary dysmenorrhea
Pain decreased significantly from baseline. However, only 9 participants completed the study, there was no placebo, and other outcomes improved without statistical significance.
Reishi – Ganoderma lucidum
Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy
Improvements were observed in fatigue, physical well-being, anxiety, depression and quality of life, along with changes in TNF-α and IL-6.
Reishi – Ganoderma lucidum
Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms
The extract produced a significantly greater reduction in IPSS than placebo. There were no significant changes in urinary flow, prostate volume, PSA or testosterone.
Panax ginseng
A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction
IIEF scores increased significantly with ginseng versus placebo; penetration, maintenance and rigidity measured by RigiScan improved.
Panax ginseng
Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction
There was significant improvement in IIEF-5, rigidity, penetration and maintenance versus placebo.
Korean white ginseng – Panax ginseng
Effects of white ginseng on reducing stress and tension by enhancing default mode network connectivity
White ginseng significantly reduced the composite stress index versus placebo, and changes in brain functional connectivity were observed. It was well tolerated.
American ginseng – Panax quinquefolius
Wisconsin Ginseng to improve cancer-related fatigue: a randomized, double-blind trial
At 8 weeks, greater improvement in fatigue was observed with American ginseng.
Siberian ginseng – Eleutherococcus senticosus
The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human
A +12% increase in VO₂ peak and +23% in time to exhaustion were reported, along with metabolic changes during exercise.
Arctic root – Rhodiola rosea
Effects of chronic Rhodiola rosea supplementation on sport performance and antioxidant capacity in trained male
It did not improve VO₂max or exercise duration, but significantly reduced post-exercise lactate and creatine kinase.
Schisandra – Schisandra chinensis
Effect of Schisandra chinensis extracts and regular low-intensity exercise on muscle strength and mass in older adults
The Schisandra group showed a significantly greater increase in knee-extensor strength.
Gotu kola – Centella asiatica
Centella asiatica improves physical performance and health-related quality of life in healthy elderly volunteer
Doses of 500 and 750 mg/day improved some lower-limb strength and physical performance parameters.
Reishi – Ganoderma lucidum
A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia
In the 123 evaluable participants, Ganopoly produced greater reductions in severity score and feelings of fatigue, as well as improved well-being versus placebo.
Andrographis + Siberian ginseng (Eleutherococcus senticosus)
Early intervention with Kan Jang® to treat upper-respiratory tract infections
The combination significantly shortened the illness by more than 21% versus placebo and significantly improved respiratory symptoms. Favorable differences in leukocytes and ESR were also observed.
Arctic root (Rhodiola rosea) + Schisandra + Siberian ginseng
Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions
The combination produced a significant improvement versus placebo in attention, speed and accuracy during cognitive tasks under stress.
Ashwagandha – Withania somnifera
Immunomodulatory Effect of Withania somnifera Extract
Significant increases were observed in IgA, IgM, IgG, IFN-γ, IL-4, CD3+/CD4+/CD8+ T cells, B cells and NK cells compared with placebo. No adverse events were reported.
Reishi – Ganoderma lucidum
Evaluation of Immune Modulation by β-1,3;1,6 D-Glucan Derived from Ganoderma lucidum
Compared with placebo, CD3+, CD4+, CD8+, the CD4/CD8 ratio, NK cells, IgA and NK-cell cytotoxicity increased significantly. The intervention was well tolerated.
Astragalus – Astragalus membranaceus
Standardized astragalus extract for attenuation of the immunosuppression induced by strenuous physical exercise
Astragalus helped maintain NK and Treg levels after intensive training and produced changes in Tδγ and IL-2/IL-10 consistent with modulation of the immune response to exertion.
Siberian ginseng – Eleutherococcus senticosus
Flow-cytometric studies with Eleutherococcus senticosus extract as an immunomodulatory agent
An increase in the absolute number of immunocompetent cells was observed, especially T-helper lymphocytes, cytotoxic lymphocytes and NK cells, with no adverse effects reported.
Noni – Morinda citrifolia
Fermented Noni Polysaccharides and Immune-Related Biomarkers in Adults with Recurrent URTIs
NK activity increased numerically versus placebo, but the primary analysis did not reach statistical significance. The per-protocol analysis did show differences at two E:T ratios, and several cytokines changed.
Reishi – Ganoderma lucidum
Effects of Ganopoly on the immune functions in advanced-stage cancer patients
Changes in cytokines and increases in CD56+ cells and NK-cell activity from baseline were observed.
Arctic root – Rhodiola rosea
A randomised, double-blind, placebo-controlled study of SHR-5 in stress-related fatigue
Rhodiola produced differences versus placebo in fatigue and certain attention measures and modified the cortisol awakening response.
Ashwagandha – Withania somnifera
An investigation into the stress-relieving and pharmacological actions of an Ashwagandha extract
Ashwagandha was associated with a significant reduction in HAM-A and morning cortisol versus placebo.
Noni – Morinda citrifolia
Noni juice improves serum lipid profiles and other risk markers in cigarette smokers
Noni consumption was associated with reduced hs-CRP, along with favorable changes in several metabolic markers versus placebo.
Sutherlandia – Lessertia frutescens
Consumption of Sutherlandia frutescens by HIV-Seropositive South African Adults
It did not change viral load or CD4 count. In addition, the burden of infectious events was higher in the Sutherlandia group, related to two tuberculosis cases in participants taking preventive isoniazid; the authors raised a possible interaction.
Butcher's broom – Ruscus aculeatus
Efficacy and safety of a Butcher's broom preparation compared to placebo in chronic venous insufficiency
Differences versus placebo were observed in leg volume and ankle and leg circumference, along with improvement in heaviness, tension and tingling.
Gotu kola – Centella asiatica
The microcirculatory activity of Centella asiatica in venous insufficiency
Microcirculation parameters improved, including skin flow, TcPO₂ and TcPCO₂, with a dose-response relationship.
Gotu kola – Centella asiatica
Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension
There was a better venoarteriolar response, increased TcPO₂, reduced TcPCO₂ and decreased leg volume.
Ginkgo biloba – EGb 761
Demonstration of the efficacy of Ginkgo biloba special extract EGb 761 on intermittent claudication
Pain-free walking distance increased more with EGb 761 than with placebo.
Ginkgo biloba – EGb 761
Effect of Ginkgo biloba on treadmill walking time among adults with peripheral artery disease
Maximum walking time increased more with Ginkgo.
Hawthorn – Crataegus
Randomised double blind placebo controlled clinical trial of Crataegus berries in NYHA II heart failure
Exercise tolerance showed a favorable difference for Crataegus versus placebo.
Gotu kola – Centella asiatica
Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs
Significant differences versus placebo were observed in leg heaviness, edema and patient overall assessment. Venous distensibility also improved in the treated groups.
Korean white ginseng – Panax ginseng
Effects of Korean White Ginseng on Vascular and Glycemic Health in Type 2 Diabetes
The 3 g dose significantly reduced the augmentation index, a marker related to arterial stiffness and hemodynamics.
Siberian ginseng – Eleutherococcus/Acanthopanax senticosus
The fruit of Acanthopanax senticosus improves arterial stiffness and blood pressure
A greater reduction in systolic blood pressure and brachial-ankle pulse wave velocity (baPWV) was observed versus placebo.
Hawthorn – Crataegus
Efficacy and safety of Crataegus extract WS 1442 in chronic stable NYHA class III heart failure
The 1,800 mg dose produced a significant increase in maximum tolerated workload during exercise versus placebo and a greater reduction in typical heart-failure symptoms.
Ginkgo biloba + Panax ginseng
Hemorrheological and circulatory effects of Gincosan
Compared with placebo, the combination showed significant differences in capillary red-cell velocity, red-cell rigidity and spontaneous platelet aggregation. The higher dose showed the most marked effect.
Ginkgo biloba + Panax ginseng
The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers
The combination produced a significant improvement in the Memory Quality Index, about 7.5%, including working and long-term memory; the effect was maintained throughout the 12 weeks of treatment.
Turmeric / Curcumin – Curcuma longa
Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial
Liver fat content improved in 78.9% with curcumin vs. 27.5% with placebo. There were also significant reductions versus placebo in ALT, AST, triglycerides, LDL, glucose and HbA1c.
Milk thistle – Silybum marianum / Silymarin
Silymarin in treatment of non-alcoholic steatohepatitis: A randomized clinical trial
The reduction in ALT and AST was significantly greater with silymarin than with placebo; ALT went from 91.3 to 38.4 U/L in the treated group.
Lycium – Lycium chinense
Lycium chinense Miller fruit extract lowers liver enzyme levels in subjects with mild hepatic dysfunction
The extract produced a significantly greater reduction in ALT (p=0.0498) and GGT (p=0.0368) versus placebo.
Korean ginseng – Panax ginseng
Effectiveness and Safety of Panax ginseng Extract on Hepatic Dysfunction: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
After 12 weeks, ALT and GGT were significantly lower in the Panax ginseng group than with placebo: p=0.009 and p=0.036, respectively.
Turmeric / Curcumin – Curcuma longa
Efficacy and Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial
Liver ultrasound improved in 75% with curcumin vs. 4.7% with placebo (p<0.001). AST and ALT also decreased significantly.
Milk thistle – Silymarin
A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury
Drug-induced liver injury occurred in 3.7% with silymarin vs. 32.1% with placebo, a clinically relevant difference; there was also a smaller decrease in SOD.
Schisandra – Schisandra chinensis
Improvement of liver function in humans using a mixture of schisandra fruit extract and sesamin
The intervention reduced ALT and AST, along with increased antioxidant capacity and lower levels of various oxidative-stress markers.
Picrorhiza – Picrorhiza kurroa
Picrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent: experimental & clinical studies
Differences between Picrorhiza and placebo were significant for bilirubin, SGOT and SGPT. Bilirubin fell to about 2.5 mg/dL in 27.4 days with Picrorhiza vs. 75.9 days with placebo.
Licorice – Glycyrrhiza / Glycyrrhizin
Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized, placebo-controlled phase I/II trial
The mean ALT reduction was 26% with glycyrrhizin vs. 6% with placebo. Treatment did not significantly reduce HCV-RNA.
Licorice – Glycyrrhizin
A Randomized Controlled Trial of Glycyrrhizin Plus Tenofovir vs. Tenofovir in Chronic Hepatitis B with Severe Acute Exacerbation
Patients who received glycyrrhizin had significantly greater reductions in AST and ALT on days 3, 5, 8 and 15. The MELD score also decreased significantly from the first week.
Ginger – Zingiber officinale
Efficacy and safety of steamed ginger extract for gastric health: a randomized, double-blind, placebo-controlled multi-center clinical trial
Ginger significantly improved total GSRS and the abdominal pain, constipation, indigestion and reflux domains versus placebo; p<0.001 for all.
Turmeric – Curcuma longa
Curcuma longa Linn versus omeprazole in treatment of functional dyspepsia: A randomized, double-blind, placebo-controlled trial
At 4 weeks, Curcuma produced a significantly greater reduction than placebo in painful and non-painful dyspepsia symptoms.
Turmeric/Curcumin + Fennel seed
Curcumin and Fennel Essential Oil Improve Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome
The relative reduction in IBS-SSS was 50.05% with curcumin + fennel vs. 26.12% with placebo (p<0.001), with improved quality of life.
Fennel seed – Foeniculum vulgare
The effect of fennel seed oil emulsion in infantile colic: a randomized, placebo-controlled study
Colic resolved by Wessel criteria in 65% with fennel vs. 23.7% with placebo (p<0.01); NNT=2.
Curcumin – Turmeric
Curcumin in Combination With Mesalamine Induces Remission in Patients With Mild-to-Moderate Ulcerative Colitis
53.8% achieved clinical remission with curcumin vs. 0% with placebo (p=0.01). Clinical response was 65.3% vs. 12.5%, and endoscopic remission was also higher.
Curcumin – Turmeric
Novel Bioenhanced Curcumin With Mesalamine for Induction of Clinical and Endoscopic Remission in Mild-to-Moderate Ulcerative Colitis
At 6 weeks, clinical remission occurred in 44.1% and endoscopic remission in 35.3% with bioenhanced curcumin, vs. 0% with placebo; p<0.01.
Curcumin – Turmeric
The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis
The decrease in SCCAI was significantly greater with curcumin than with placebo (-5.9 vs. -2.1; p=0.001). Quality of life, hs-CRP and ESR also improved.
Curcumin – Turmeric
Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial
Over 6 months, 4.65% relapsed with curcumin vs. 20.51% with placebo (p=0.040); the intention-to-treat analysis also showed a significant difference (p=0.049). Clinical and endoscopic indices also improved.
Ginger – Zingiber officinale
Effect of ginger on gastric motility and symptoms of functional dyspepsia
Gastric emptying was significantly faster with ginger: 12.3 vs. 16.1 minutes (p≤0.05).
Ginger – Zingiber officinale
Effect of a Standardized Ginger Root Powder Regimen on Chemotherapy-Induced Nausea and Vomiting
Ginger produced significant improvement in nausea-related quality of life, severity of delayed nausea and frequency of delayed nausea and vomiting in later cycles.
Turmeric / Curcumin + Fennel seed / Fennel essential oil
Curcumin and Fennel Essential Oil Improve Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome
The relative reduction in IBS-SSS was 50.05% with curcumin + fennel vs. 26.12% with placebo (p<0.001). Abdominal pain also decreased significantly and all IBS-SSS components improved. The share of symptom-free patients was 25.9% vs. 6.8% with placebo (p=0.005), along with a consistent improvement in quality of life.
No studies match that search.
These studies refer to the individual ingredients, evaluated independently in the scientific literature indexed in PubMed. They are not clinical evidence for the finished Adaptoheal products and are provided for informational purposes.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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